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A preview of the 2007 Detroit Auto Show, including a Mitsubishi concept, the Jaguar XF, and the Lexus F series. CNETs Brian Cooley and our Car Tech crew will be covering the event starting January 8.
Special edition Maserati ramps up the cabin tech. We take a first look at the 2008 Detroit auto show.
Get a hands-on look at Nissans electric utility vehicle.
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BOL 1034: Life is short, have pie
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Created: 01/15/2013 Facebooks new smart search tool challenges Yelp, LinkedIn and Google. Also, new car tech unveiled at the Detroit Auto Show includes eye tracking, and hand gestures to change radio stations.
Hyundai unveils the stylized Genesis Concept
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-Searching for tech journalists who live in New York and like StarTech? Well, Im Bridget Carey and this is your CNET update. Facebook has unveiled a new way to search within the site and your connections. Its called Graph Search. Unlike Google where you type in a keyword, you can hand for things more naturally by narrowing down different fields. The Graph Search has focused on people photos, places, and interest. A example is searching for restaurants in Chicago or music my friends like. Take it to another level and you can search for friends in New York that like the show Friends. Another example Mark Zuckerberg gave was searching for Mexican restaurants in Palo Alto that his friends have been too. That way, you could reach out your friends to get recommendations that the place is any good. If you meet someone, but you forgot their full name, theres a way to do that too. Search for people name Chris who are friends of Lars and went to Standford University. The search can also help in professional connections. One example given was a search for NASA employees who are friends with Facebook employees, or maybe you wanna search for a doctor or dentist liked by your friends. Facebook is taking on Yelp and linked in with this new Graph Search. It also is taken on Google by leading you search for some things outside of your circle of friends. For example, search for restaurants in your area liked by graduates of the Culinary Institute of America and you just found something that not even Google can give you. But you have to sign up on a waitlist to try out the new feature. Its still a data product. The Detroit Auto Show is going on now and were seeing more cars unveiled with advance technology. They can assist with driving and heavy traffic. The Mercedes Benz E-Class update features things like brake assist and cross-traffic assist to help a driver avoiding accident. In 2014, Infiniti Q50 uses cameras to help keep the cars centered in its lane. A Hyundai concept car called the Genesis takes things a bit further and uses eye-tracking technology with a display located near the center of the windshield. The idea is that drivers glance to icon they want and confirm it with a knob by the controls. Drivers can also change radio stations by waiving their hand or just the volume by twisting an imaginary knob. I hate to see what happens as theres a flyer trying to show your way, but honestly I think it will be a long time before we see this kind of technology manifest itself in a safe way in a real car. And today, were looking at the iPhone app birthday cards by Cleverbug. Its another app that lets you send personalized greeting cards from your phone, but it uses Facebook to let you know who has an upcoming birthday and you can insert photos from Facebook. Sending the physical card costs you $3, but you can also post a digital version on a timeline. Its a much more unique way to wish someone a happy birthday than the usual wall post. Thats your tech news update. You can get links to all of the stories I mentioned at our blog cnet.com/upFacebook Graph Search takes on Googledate. From our studios in New York, Im Bridget Carey.
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Disrepute according to whom, some might wonder.
This isnt the first end-of-year Facebook fumble that has occurred in the Philippines this week. For the Inquirer also reports on a girl at St. Theresas College high school in Cebu City. She -- are you ready? -- posted a Facebook photo of herself in a bikini.
Some might emphasize that different cultures have their own different sense of morals. Others might simply ask the question: Ample for whom?
Its not that the United States is immune from schools that have little appreciation for the nuances of social networking, or indeed, teenage life.
The school has now eased on the former, but not on the latter, even though it seems to be largely a symbolic gesture and wont prevent the boys from enrolling in universities (the school will give them certification to do that).
According to the Inquirer,Online Education- A Benefit For Everybody. the boys may not have realized that everyone could see these photos. And, yes, scandal appears to have ensued at the Innt Jesus Academy in Marikina City.
Have the worlds schools caught up with this social-networking thing? Or even with this Web thing? Or even with this being a teenager thing?
I do worry about adults sometimes.
Chris MatyszczykChris Matyszczyk is an award-winning creative director who advises major corporations on content creation and marketing. He brings an irreverent, sarcastic, and sometimes ironic voice to the tech world.
The boys reportedly explained that this was mere simulation. They were not naughty kissers. They were merely using camera tricks to, well, Mariners Christian School - Costa Mesa California - CA - School overview mariners christian school amuse. The school was anything but. They were initially told they couldnt participate in graduation ceremonies or collect their vital diplomas.
Just the other day, a high school in Indiana expelled a student for tweeting: F is one of those F words you can F put anywhere in a F sentence and it still F makes sense.
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Multiple Endocrine Neoplasia Type 1 Overview
How Common is MEN 1?
The most reliable way to determine if MEN 1 gene has been inherited is to do a genetic test (predictive genetic testing). Recent advances have made it possible to perform predictive genetic testing at any age. This requires only a single blood sample.
Does MEN 1 Cause Cancer?
The pancreasis the next most commonly affected gland in MEN 1. Many people who inherit MEN 1 develop small pancreatic adenoma which can be detected by measuring pancreatic hormones in the blood. If suspected, aCT scanorultrasound scanis usually done to examine the pancreas more closely. These adenomas do not usually produce symptoms and are mostly less than 3cm in diameter. Occasionally cancerous (malignant) pancreatic tumors develop. For this reason, it is recommended people with MEN 1 have regular blood screens of the pancreatic hormones, and even scans of the pancreas to detect the minority of pancreatic lumps which are at risk for developing malignancy. Malignancy of the pancreas is rare prior to 30 years of age.
The parathyroid glands, pituitary gland, and pancreas are most commonly affected.Theparathyroid glandsare affected in almost everyone who inherits MEN 1. They are often the first endocrine glands to show signs of overactivity. Parathyroid gland overactivity (known ashyperparathyroidism) often develops during the teenage years. However, over 95% of people with MEN 1 will have parathyroid gland overactivity by age 30 years. Many people with hyperparathyroidism related to MEN 1 do not develop obvious symptoms until they are over 30 years of age.
Will a Person with MEN 1 Always Know that MEN 1 Runs in Their Family?
If a person has inherited MEN 1, they should have regular screening for endocrine gland over-activity. This involves periodic blood tests (about 2 per year) and occasional scans. These blood tests and scans are done in order to detect endocrine gland over-activity and adenoma at an early stage. Early detection of endocrine gland over-activity and adenoma allows any necessary treatment to be started before complications develop.
A person willnotalways know that MEN 1 runs in their mily. In some milies, relatives are unaware that there is a history MEN 1. The symptoms of MEN 1 are extremely variable; some people live to old age with few health problems. Also, many of the health problems associated with MEN 1 occur frequently in the general population. Conditions such as stomach ulcers, kidney stones, and tiredness are all very common among people without MEN 1. For these reasons, MEN 1 may go unrecognized in a mily.
Most of the endocrine problems related to MEN 1 are not cancerous (malignant). However, malignancy can occur and is one reason why people who inherit the MEN 1 gene need regular tests. If malignancy develops, it is most likely to occur in relation to the pancreas andthymus(the thymus is in the chest). Malignancy in MEN 1 is rare before 30 years of age, and most people with MEN 1 never develop a malignancy due to MEN 1. It is believed that regular tests will lead to early diagnosis of malignancy. It is hoped early diagnosis of such tumors will reduce the likelihood of serious complications.
What Tests Are Needed if a Person Has Inherited MEN 1?
Can MEN 1 Be Prevented or Cured?
parathyroid tumors Disorders of the Parathyroid, Pituitary, and Pancreas,Almost everyone who inherits MEN 1 develops over-activity of the parathyroid glands (hyperparathyroidism) at some stage in their life. The other endocrine glands become over-active less frequently; however, people who inherit MEN 1 will usually develop over-activity in more than one endocrine gland. Over-activity in different endocrine glands may occur simultaneously or at separate times during a persons life.
Because MEN 1 is caused by a malfunctioning gene, which is present in every cell of the body, it is not possible to cure MEN 1. Curing MEN 1 would require replacing the malfunctioning gene in billions of the bodys cells. It is possible that in the future drugs will be developed to prevent MEN 1 related endocrine gland overactivity. However, in the foreseeable future the treatment of people with MEN 1 will continue to be based on regular tests, early diagnosis of problems, and appropriate treatment (almost always surgical removal of the over-active adenomas).
The health problems caused by inheriting MEN 1 can usually becontrolledwith the right treatment.
The Effect of MEN 1 on the Endocrine Glands
People who inherit the gene for MEN 1 are pre-disposed to developing an over-activity in hormone production from the parathyroid glands, pituitary gland, and pancreas. Increased hormone production is usually associated with enlargement of these glands. Endocrine gland enlargement and hormone overproduction does not usually occur in all areas of an endocrine gland at the same point in time. Some parts of overactive endocrine glands grow more rapidly than others, and produce more hormone than other parts of the same gland. The parts of an endocrine gland which grow most rapidly become "lumpy." These lumps are usuallybenign tumors. Benign tumors in endocrine glands are known asadenomas.
Who Needs to Be Tested for Inheritance of the MEN 1 Gene?
MEN 1 andMEN 2are completely different conditions due to quite separate genes. The behavior and type of endocrine over-activity is different. MEN 1 is also known as MEA 1 (Multiple Endocrine Adenomatosis Type 1) and Wermers Syndrome (after Dr. Wermer).
The blood tests measure the level of:
What Age Does MEN 1 Usually Present Itself?
Gastrincauses stomach ulcers and is produced by overactivity in the region of the pancreas. Gastrinomas are the most common neuroendocrine tumor of the pancreas which occurs with MEN 1. Although the pancreas can have endocrine tumors of insulin secreting cells or other hormones, gastrin is the most common.
This information is not designed to replace a physicians independent judgment about the appropriateness or risks of a procedure for a given patient. Always consult your doctor about your medical conditions. Vertical Health & EndocrineWeb do not provide medical advice, diagnosis or treatment. Use of this website is conditional upon your acceptance of our user agreement.
In general, the likelihood of endocrine gland over-activity and the development of adenoma increases with age. By age 30, most people who inherit MEN 1 will have some type of endocrine gland over-activity. Over-activity from the adenoma can usually be detected by special blood tests (measurement of ionized calcium and parathyroid hormone in the blood) before people reach age 30. Symptoms, however, do not develop in many people with MEN 1 until they are older than 30. For this reason it is important for all people at risk to be tested for MEN 1, even though they may feel quite well.
MEN 1 is a rare condition.It occurs in about 1 person in every 30,000 people.
To understand fully what this over-activity means, heres a review of the endocrine system and what it does: Endocrine glands each produce different and specific hormones. Hormones are chemicals that regulate the function of various tissues throughout the body (see our article on theendocrine system). The endocrine glands release a controlled amount of their hormone directly into the blood stream. Once in the blood stream, hormones circulate throughout the body. Only small quantities of hormones are needed to produce the required effect throughout the body. Under normal circumstances, the level of endocrine gland activity is carefully regulated by the body.
Only a very small proportion of people with endocrine disorders have MEN 1. Most endocrine problems have nothing to do with MEN 1. The endocrine disorders which may be related to MEN parathyroid tumors Disorders of the Parathyroid, Pituitary, and Pancreas1 are those in which the parathyroid gland, pancreas, and pituitary gland become overactive. Less than 1% of all people with parathyroid over-activity (hyperparathyroidism) or pituitary tumors have MEN 1. Certain types of pancreatic endocrine tumors (gastrinoma Zollinger-Ellison syndrome and insulinoma) are more likely to be related to MEN 1. People who have overactivity of 2 or more of the above endocrine glands should be examined for MEN 1.
The Endocrine Glands Usually Affected by MEN 1
those for screening people for endocrine gland over-activity. Only people who have inherited the MEN 1 gene are at an increased risk of developing the MEN 1 syndrome.
Multiple endocrine neoplasia page. Genetics Home Reference Web site. Available at: April 2006. Accessed May 20, 2010.
MEN 1 can lead to over-activity and enlargement of 3 endocrine glands: the parathyroid glands, the pancreas, and the pituitary gland.
Different endocrine glands become over-active at different times in life. Similarly, different areas within one endocrine gland will become overactive (or develop adenoma) at different times during life. Additionally, the effect of MEN 1 varies from person to person; there is no "standard" with MEN 1.
Parathyroid hormoneandcalcium(and ionized calcium) to detect hyperparathyroidism (often the first sign of MEN 1).
Does MEN 1 Affect Life Expectancy?
Tests to determine if the MEN 1 gene has been inherited are the most important tests to do if a mily member has the gene.
Those individuals with a positive genetic test result should have regular tests for endocrine gland over-activity. Genetic testing is not usually part of routine MEN 1 blood testing. If you would like more information on the criteria for genetic testing, please discuss the issue with your doctor. Some people may live in places where MEN 1 genetic testing is not be available. Under this circumstance, regular screening for endocrine gland overactivity is usually offered to all individuals with a strong mily history of MEN 1.
Should Everyone with an Endocrine Gland Problem Be Tested for MEN 1?
MEN 1 is passed dparathyroid tumorsown in milies from one generation to the next. MEN 1 can be inherited by a child if one of their parents has MEN 1.
How Is Inheritance of the MEN 1 Gene Diagnosed?
Over-production of pancreatic hormones is common in MEN 1. Many different types of pancreatic hormones can be over-produced (see our page onpancreatic hormones). Some hormones are frequently over-produced without causing symptoms (such as pancreatic polypeptide), while other hormones such as gastrin (which can cause severe stomach ulcers and diarrhea) and insulin (which can produce a low blood sugar) may cause important symptoms and ill-health. Insulin over-production is most common in people under 30 years of age, whereas gastrin over-production is is most common after 30 years of age.
The DNA in the blood sample is analyzed for the presence of an abnormal MEN 1 gene. People with an abnormal MEN 1 gene are said to have apositiveresult. This test can detect MEN 1 even when all other tests are normal. A negative genetic test result means that a person does not have MEN 1, nor can they pass MEN 1 to their children.
People with a mily history of MEN 1 as well as those individuals in whom illness may be related to MEN 1 require tests to determine if they have inherited the MEN 1 gene.
Multiple endocrine neoplasia type 1 (MEN1) is a relatively uncommoninheriteddisease. Individuals who inherit the gene for MEN 1 have an increased chance of developing over-activity and enlargement of certain endocrine glands. The endocrine glands most commonly affected by MEN 1 are theparathyroid glands,thepancreas, and thepituitary glands.
Is MEN 1 the Same as MEN 2?
The majority of people with MEN 1 live beyond 65 years of age. With regular tests and appropriate treatment (when necessary), most people with MEN 1 can expect to live a long and productive life. Regular medical follow-up is, however, essential.
Multiple Endocrine Neoplasia Type 1 page. National Endocrine and Metabolic Diseases Information Service Web site. Available at: November 2009. Accessed May 20, 2010.
